Individual generic drug information

clofazimine

Reference monograph

Part of registered formulation

CLOFAZIMINE

Reference record: Clofazimine
Source: BNF 80 (2020–2021)
Printed source pages: 632
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Clofazimine only.

Indications And Dose

Multibacillary leprosy in combination with rifampicin and dapsone (3-drug regimen) (administered on expert advice) ▶BY MOUTH ▶Adult: 300 mg once a month, to be administered under supervision and 50 mg daily, to be self-administered, alternatively 300 mg once a month, to be administered under supervision and 100 mg once daily on alternate days, to be self-administered Lepromatous lepra reactions (administered on expert advice) ▶BY MOUTH ▶Adult: 300 mg daily for max. 3 months Severe type II (erythema nodosum leprosum) reactions (administered on expert advice) ▶BY MOUTH ▶Adult: 100 mg 3 times a day for one month, subsequent dose reductions are required, may take 4–6 weeks to attain full effect

Source page 632

Cautions

Avoid if persistent abdominal pain and diarrhoea. may discolour soft contact lenses

Source page 632

Safety

Extracted information for Clofazimine only.

Interactions

→Appendix 1: clofazimine

Source page 632

Side Effects

Abdominal pain. appetite decreased. dry eye. eye discolouration. fatigue. gastrointestinal disorders. hair colour changes (reversible). headache. lymphadenopathy. nausea. photosensitivity reaction. red discolouration of body ﬂuids. skin discolouration (including areas exposed to light). skin reactions. splenic infarction. urine red. visual impairment. vomiting (hospitalise if persistent). weight decreased

Source page 632

Pregnancy

Use with caution.

Source page 632

Breast Feeding

May alter colour of milk; skin discoloration of infant.

Source page 632

Hepatic Impairment

Use with caution.

Source page 632

Renal Impairment

Use with caution.

Source page 632

Dose and formulations

Extracted information for Clofazimine only.

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: capsule Capsule CAUTIONARY AND ADVISORY LABELS 8, 14, 21 ▶Clofazimine (Non-proprietary) Clofazimine 50 mg Lamprene 50mg capsules | 100 capsule P s

Source page 632

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

300 mg once a month, to be administered under

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 632

Adults

First line only; read the complete Indications and dose section above.

300 mg daily for max. 3 months

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 632

Adults

First line only; read the complete Indications and dose section above.

100 mg 3 times a day for one month, subsequent

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 632

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

clofazimine

Reference monograph

Part of registered formulation

CLOFAZIMINE

Reference record: Clofazimine
Source: BNF 80 (2020–2021)
Printed source pages: 632
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Clofazimine only.

Indications And Dose

Source page 632

Cautions

Avoid if persistent abdominal pain and diarrhoea. may discolour soft contact lenses

Source page 632

Safety

Extracted information for Clofazimine only.

Interactions

→Appendix 1: clofazimine

Source page 632

Side Effects

Source page 632

Pregnancy

Use with caution.

Source page 632

Breast Feeding

May alter colour of milk; skin discoloration of infant.

Source page 632

Hepatic Impairment

Use with caution.

Source page 632

Renal Impairment

Use with caution.

Source page 632

Dose and formulations

Extracted information for Clofazimine only.

Medicinal Forms

Source page 632

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

300 mg once a month, to be administered under

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 632

Adults

First line only; read the complete Indications and dose section above.

300 mg daily for max. 3 months

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 632

Adults

First line only; read the complete Indications and dose section above.

100 mg 3 times a day for one month, subsequent

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 632

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.