Therapeutic Action
Antiseizure (anticonvulsant), muscle relaxant, sedative, anxiolytic
Source page 389
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Individual generic drug information
Extracted information for DIAZEPAM only.
Antiseizure (anticonvulsant), muscle relaxant, sedative, anxiolytic
Source page 389
First-line treatment of convulsive status epilepticus Muscle spasms due to tetanus Severe agitation in adults
Source page 389
Extracted information for DIAZEPAM only.
Do not administer to neonates (contains benzyl alcohol) and to patients with severe respiratory insufficiency or severe hepatic impairment. Administer with caution: to older patients and patients with renal or hepatic impairment (reduce the dose by half); to patients with history of substance abuse or mental disorders. May cause: pain at injection site; hypotension, muscle weakness, ataxia, hypotonia, drowsiness, lethargy, confusional state; respiratory depression, especially if injected rapidly by IV route and if large doses are administered; coma in the event of overdose. Avoid or monitor in combination with: opioid analgesics, antipsychotics, first-generation antihistamines (hydroxyzine, promethazine), antidepressants, other antiseizure medications, etc. (increased sedation); enzyme inducers such as rifampicin, rifabutin, nevirapine, phenobarbital, phenytoin, carbamazepine, etc. (reduced effect of diazepam); omeprazole, macrolides, ritonavir, isoniazid, fluconazole, itraconazole, etc. (increased diazepam toxicity); phenytoin (increased phenytoin toxicity). Pregnancy and breast-feeding: avoid, except if vital (passage through the placenta and breast milk)
Source pages 390, 391
Extracted information for DIAZEPAM only.
10 mg in 2 ml ampoule (5 mg/ml) for IM injection, slow IV injection (3 to 5 minutes) or IV infusion in 0.9% sodium chloride or 5% glucose The injectable solution may be used rectally.
Source page 389
Convulsive status epilepticus Child 1 month to 11 years: Rectal route: one dose of 0.5 mg/kg (0.1 ml/kg); max. 10 mg (2 ml) Slow IV injection: one dose of 0.2 to 0.3 mg/kg (0.04 to 0.06 ml/kg); max. 10 mg (2 ml) 10 mg/2 ml solution Age Weight Rectal route IV injection 1 to < 4 months 3 to < 6 kg 0.4 ml 0.25 ml 4 to < 12 months 6 to < 10 kg 0.7 ml 0.4 ml 1 to < 3 years 10 to < 15 kg 1.2 ml 0.6 ml 3 to < 5 years 15 to < 20 kg 1.5 ml 1 ml 5 to < 9 years 20 to < 30 kg 2 ml 1.2 ml 9 to < 12 years 30 to < 40 kg 2 ml 2 ml Child 12 years and over and adult: Rectal route: one dose of 10 to 20 mg (2 to 4 ml); one dose of 10 mg (2 ml) in older patients Slow IV injection: one dose of 10 mg (2 ml); one dose of 5 mg (1 ml) in older patients In children and adults, if seizures do not stop 5 minutes after the first dose, readminister the same dose, regardless of the route of administration. Do not administer more than 2 doses in total. Muscle spasms due to tetanus The dosage range is variable, depending on the severity of symptoms and clinical response. For information: Child 1 month and over and adult: 0.1 to 0.3 mg/kg by slow IV injection every 1 to 4 hours or 0.1 to 0.5 mg/kg/hour by IV infusion over 24 hours Severe agitation Adult: 10 mg (2 ml) by IM injection, to be repeated once after 30 to 60 minutes if necessary
Source pages 389, 390
Lay the patient on their side. For volumes up to 1 ml, use a 1 ml syringe. Withdraw the required dose. Remove the needle. Insert the syringe into the rectum for a length of 1 to 3 cm (depending on age) to administer the dose. For volumes greater than 1 ml, use a 2 ml syringe and attach to the tip of the syringe a nasogastric tube n°8 cut to a length of 2 to 3 cm to administer the dose. After administration, hold the buttocks together for at least one minute.
Source page 390
Extracted information for DIAZEPAM only.
Diazepam is subject to international controls: follow national regulations. For administration by IV infusion, the concentration of diazepam in the solution should not exceed 0.25 mg/ml (e.g. 1 mg in at least 4 ml). Diazepam slow IV is also used in delirium tremens (alcohol withdrawal) in adults: 10 to 20 mg every 4 to 6 hours under close supervision in intensive care unit. Do not mix with other drugs in the same syringe or infusion.
Source page 391
– Below 25 °C
Source page 391
Filter the extracted dose blocks for this individual drug.
0.1 to 0.3 mg/kg by slow IV injection every 1 to 4 hours or 0.1 to
Candidate age grouping · source page 390
10 mg (2 ml) by IM injection, to be repeated once after 30 to 60 minutes if necessary
Candidate age grouping · source page 390