Therapeutic Action
Oxytocic drug, prostaglandin analogue
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Individual generic drug information
Extracted information for MISOPROSTOL only.
Oxytocic drug, prostaglandin analogue
Source page 220
Incomplete abortion Termination of intra-uterine pregnancy, preferably in combination with mifepristone Induction of labour Treatment of post-partum haemorrhage due to uterine atony, when injectable oxytocics are not available or ineffective Cervical dilation before aspiration or curettage
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Extracted information for MISOPROSTOL only.
For induction of labour if the foetus is viable: Do not administer in the event of previous caesarean section. Administer with caution in case of grand multiparity or overdistention of the uterus (risk of uterine rupture). Monitor the intensity and frequency of contractions as well as foetal heart rate after administration of misoprostol. Do not administer simultaneously with oxytocin. At least 4 hours must have elapsed since the last administration of misoprostol before oxytocin can be given. For incomplete abortion or termination of pregnancy after 13 weeks since the last menstrual period: reduce the dose by half in the event of 2 or more previous caesarean sections. May cause: dose-dependent diarrhoea, vomiting, uterine hypertony, headache, fever, chills, foetal heart rhythm disorders, foetal distress. Breast-feeding: no contra-indication
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Extracted information for MISOPROSTOL only.
25 micrograms and 200 micrograms tablets
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Incomplete abortion Up to 13 weeks since the last menstrual period: 400 micrograms single dose sublingually or 600 micrograms single dose orally From 13 to 22 weeks since the last menstrual period: 400 micrograms sublingually every 3 hours Termination of pregnancy Up to 13 weeks since the last menstrual period: 800 micrograms single dose sublingually or nd vaginally. If expulsion has not occurred within 24 hours administer a 2 dose of 800 micrograms. From 13 to 22 weeks since the last menstrual period: 400 micrograms single dose sublingually or vaginally every 3 hours Induction of labour 25 micrograms orally every 2 hours, or if not possible, vaginally every 6 hours, until labour starts (max. 200 micrograms per 24 hours) Treatment of post-partum haemorrhage 800 micrograms single dose sublingually Cervical dilation before aspiration or curettage 400 micrograms single dose sublingually 1 to 3 hours before the procedure or vaginally 3 hours before the procedure
Source pages 220, 221
Extracted information for MISOPROSTOL only.
Do not use misoprostol in ectopic or molar pregnancy. Rectal route is used for the treatment of post-partum haemorrhage when the sublingual route cannot be used. Also comes is 25 micrograms vaginal tablet for induction of labour (every 6 hours until labour starts). These tablets are intended to be used by vaginal route only.
Source page 221
– – Below 25 °C
Source page 221
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