Therapeutic Action
Cycline antibacterial
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Individual generic drug information
Extracted information for DOXYCYCLINE only.
Cycline antibacterial
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Cholera, uncomplicated cutaneous anthrax, louse-borne and tick-borne relapsing fevers, epidemic typhus and other rickettsioses, plague, brucellosis, leptospirosis, lymphogranuloma venereum Lymphatic filariasis, alternative to ivermectin in onchocerciasis Alternative to first-line treatments of treponematosis, atypical pneumonia (Mycoplasma pneumoniae, Chlamydophila pneumoniae), cervicitis and urethritis due to Chlamydia trachomatis (in combination with a treatment for gonorrhoea), donovanosis, syphilis
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Extracted information for DOXYCYCLINE only.
Do not administer to patients with allergy to cyclines. Do not administer treatments longer than 21 days in children under 8 years (risk of discolouration of teeth). Administer with caution to patients with hepatic or renal impairment. May cause: gastrointestinal disturbances, allergic reactions, photosensitivity (protect exposed skin from sun exposure), oesophageal ulcerations (take tablets during meals with a glass of water in an upright position and at least 1 hour before going to bed). Do not give simultaneously with ferrous salts, zinc sulfate, calcium carbonate, antiacids (aluminium/magnesium hydroxide, etc.): administer 2 hours apart. Monitor combination with hepatic enzyme inducers: rifampicin, phenobarbital, phenytoin, carbamazepine, etc. (reduction of the doxycycline efficacy). nd rd Pregnancy: avoid during the 2 and 3 trimester (risk of discolouration and malformation of teeth). Use only for severe infections when doxycycline is the most effective option, and the benefits outweigh the risks. No contra-indication for single dose treatments. Breast-feeding: avoid if possible (risk of infant teeth discolouration) or do not exceed 10 days of treatment if there is no alternative.
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Extracted information for DOXYCYCLINE only.
100 mg tablet
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Louse-borne relapsing fever, epidemic typhus, cholera Child: 4 mg/kg (max. 100 mg) single dose Adult: 200 mg (300 mg in cholera) single dose Plague Child under 45 kg: 4.4 mg/kg (max. 200 mg) on D1 then 2.2 mg/kg (max. 100 mg) 2 times daily Child 45 kg and over and adult: 200 mg on D1 then 100 mg 2 times daily Other indications Child under 45 kg: 2 to 2.2 mg/kg (max. 100 mg) 2 times daily Child 45 kg and over and adult: 100 mg 2 times daily In severe infections, a loading dose (as for plague) is recommended.
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Rickettsiosis: 5 to 7 days or until 3 days after fever has disappeared Leptospirosis, cervicitis and urethritis due to C. trachomatis: 7 days Cutaneous anthrax, tick-borne relapsing fever: 7 to 10 days Plague, atypical pneumonia: 10 to 14 days Early syphilis, bejel, pinta, lymphogranuloma: 14 days Filariasis: minimum 4 weeks Late latent syphilis: 30 days Brucellosis: 6 weeks Donovanosis: until complete healing of lesions
Source pages 125, 126
Extracted information for DOXYCYCLINE only.
Doxycycline is also used: as an alternative to first-line treatment for septicaemia of pulmonary origin (dose as for plague), in combination with other antibacterials; for prophylaxis of plague, scrub typhus and leptospirosis.
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– – Below 25 °C
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Filter the extracted dose blocks for this individual drug.
4 mg/kg (max. 100 mg) single dose
Candidate age grouping · source page 125
200 mg (300 mg in cholera) single dose
Candidate age grouping · source page 125
4.4 mg/kg (max. 200 mg) on D1 then 2.2 mg/kg (max. 100 mg) 2 times daily
Candidate age grouping · source page 125
200 mg on D1 then 100 mg 2 times daily
Candidate age grouping · source page 125
2 to 2.2 mg/kg (max. 100 mg) 2 times daily
Candidate age grouping · source page 125
100 mg 2 times daily
Candidate age grouping · source page 125