Individual generic drug information
Extracted information for Etravirine only.
HIV infection resistant to other non-nucleoside reverse transcriptase inhibitor and protease inhibitors in combination with other antiretroviral drugs (including a boosted protease inhibitor) ▶BY MOUTH ▶Adult: 200 mg twice daily, to be taken after food
Source page 704
Acute porphyrias p. 1120
Source page 704
Dispense in original container (contains desiccant).
Source page 704
Extracted information for Etravirine only.
→Appendix 1: etravirine
Source page 704
▶Common or very common Diabetes mellitus. diarrhoea. headache. hyperglycaemia. myocardial infarction. nausea . skin reactions. vomiting ▶Uncommon Angioedema. bronchospasm. dry mouth. dyslipidaemia. gynaecomastia. haematemesis. hepatic disorders. hyperhidrosis. hypersensitivity. hypersomnia. numbness. pancreatitis. sluggishness. vision blurred ▶Rare or very rare Severe cutaneous adverse reactions (SCARs) ▶Frequency not known Haemorrhagic stroke. osteonecrosis. weight increased SIDE-EFFECTS, FURTHER INFORMATION Hypersensitivity reactions Rash, usually in the second week, is the most common side-effect and appears more frequently in females. Life-threatening hypersensitivity reactions reported usually during week 3–6 of treatment and characterised by rash, eosinophilia, and systemic symptoms (including fever, general malaise, myalgia, arthralgia, blistering, oral lesions, conjunctivitis, and hepatitis). Discontinue permanently if hypersensitivity reaction or severe rash develop. If rash mild or moderate (without signs of hypersensitivity reaction), may continue without interruption—usually resolves within 2 weeks.
Source page 704
Manufacturer advises caution in moderate impairment and in patients with hepatitis B or C (increased risk of hepatic side effects); avoid in severe impairment (no information available).
Source page 704
Extracted information for Etravirine only.
Patients with swallowing difficulties may disperse tablets in a glass of water just before administration.
Source page 704
There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 21 ▶Intelence (Janssen-Cilag Ltd) Etravirine 100 mg Intelence 100mg tablets | 120 tablet P £301.27 Etravirine 200 mg Intelence 200mg tablets | 60 tablet P £301.27
Source page 704
Extracted information for Etravirine only.
Hypersensitivity reactions Patients or carers should be told how to recognise hypersensitivity reactions and advised to seek immediate medical attention if hypersensitivity reaction or severe rash develop. Missed doses If a dose is more than 6 hours late, the missed dose should not be taken and the next dose should be taken at the normal time.
Source page 704
Filter the extracted dose blocks for this individual drug.
First line only; read the complete Indications and dose section above.
200 mg twice daily, to be taken after food
This is a first-line fragment. Read the full Indications and Dose section above.
Candidate age grouping · source page 704
