Individual generic drug information

gliclazide

Reference monograph

Part of registered formulation

GLICLAZIDE + METFORMIN HYDROCHLORIDE

Reference record: GLICLAZIDE
Source: MSF Essential Drugs (January 2026)
Printed source pages: 155, 156
Age groups indexed: Not recorded

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for GLICLAZIDE only.

Therapeutic Action

Sulfonylurea antidiabetic

Source page 155

Indications

Second-line treatment of type 2 diabetes, in patients over 60 years: as monotherapy, when metformin is not tolerated or contra-indicated in combination with metformin, when glycaemic control is inadequate with metformin alone

Source page 155

Safety

Extracted information for GLICLAZIDE only.

Contraindications Adverse Effects Precautions

Do not administer in the event of: allergy to sulfonamides; type 1 diabetes, juvenile diabetes, ketoacidosis; severe renal or hepatic impairment. May cause: hypoglycaemia, gastrointestinal disturbances, weight gain; rarely, allergic reactions. Monitor combination with: diuretics, angiotensin-converting enzyme inhibitors, non-steroidal anti-inflammatories, azole antifungals (fluconazole, miconazole), ciprofloxacin, erythromycin, co-trimoxazole (enhanced hypoglycaemic effect); rifampicin (decreased hypoglycaemic effect); drugs increasing blood glucose levels: corticosteroids, hydrochlorothiazide, salbutamol, chlorpromazine. Avoid combination with alcohol (risk of hypoglycaemia). Pregnancy: avoid. Insulin is the drug of choice for the treatment of type 2 diabetes in pregnant women (improved glycaemic control; reduced risk of foetal anomalies and neonatal complications). Breast-feeding: CONTRA-INDICATED

Source pages 155, 156

Dose and formulations

Extracted information for GLICLAZIDE only.

Forms And Strengths

80 mg scored tablet

Source page 155

Dosage And Duration

Adult: Weeks 1 and 2: 40 mg once daily in the morning Increase if necessary in increments of 40 mg every 2 weeks, according to blood glucose levels (Weeks 3 and 4: 80 mg once daily in the morning). The usual dose is 80 to 160 mg daily (max. 240 mg daily).

Source page 155

Clinical care

Extracted information for GLICLAZIDE only.

Remarks

Take with meals (reduced risk of gastrointestinal disturbances). For doses greater than 80 mg daily, divide the daily dose into 2 doses. Also comes in 30 and 60 mg modified release tablets.

Source page 156

Storage

- Below 25 °C

Source page 156

Dose text by age group

Filter the extracted dose blocks for this individual drug.

No dose block was identified for this age filter. This does not establish whether the drug is suitable for that age group.

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

gliclazide

Reference monograph

Part of registered formulation

GLICLAZIDE + METFORMIN HYDROCHLORIDE

Reference record: GLICLAZIDE
Source: MSF Essential Drugs (January 2026)
Printed source pages: 155, 156
Age groups indexed: Not recorded

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for GLICLAZIDE only.

Therapeutic Action

Sulfonylurea antidiabetic

Source page 155

Indications

Source page 155

Safety

Extracted information for GLICLAZIDE only.

Contraindications Adverse Effects Precautions

Source pages 155, 156

Dose and formulations

Extracted information for GLICLAZIDE only.

Forms And Strengths

80 mg scored tablet

Source page 155

Dosage And Duration

Source page 155

Clinical care

Extracted information for GLICLAZIDE only.

Remarks

Take with meals (reduced risk of gastrointestinal disturbances). For doses greater than 80 mg daily, divide the daily dose into 2 doses. Also comes in 30 and 60 mg modified release tablets.

Source page 156

Storage

- Below 25 °C

Source page 156

Dose text by age group

Filter the extracted dose blocks for this individual drug.

No dose block was identified for this age filter. This does not establish whether the drug is suitable for that age group.

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.