Indications And Dose
Maintenance in schizophrenia and schizoaffective disorder [in patients currently stabilised on oral haloperidol] ▶BY DEEP INTRAMUSCULAR INJECTION ▶Adult: Initially 25–150 mg every 4 weeks, initial dose should be based on previous daily dose of oral haloperidol (10–15 times the daily dose of oral haloperidol is recommended), adjusted in steps of up to 50 mg every 4 weeks if required, adjustment of the dosing interval may be required, depending on individual patient response; usual maintenance 50–200 mg every 4 weeks (max. per dose 300 mg every 4 weeks), dose to be administered into gluteal muscle, the individual benefit-risk should be assessed when considering doses above 200 mg every 4 weeks, if supplementation with oral haloperidol is required, the combined total dose of haloperidol from both formulations must not exceed the corresponding maximum oral haloperidol dose of 20 mg per day ▶Elderly: Initially 12.5–25 mg every 4 weeks, increased if necessary to 25–75 mg every 4 weeks, adjustment of the dosing interval may be required, depending on individual patient response, dose to be administered into gluteal muscle, doses above 75 mg every 4 weeks should only be considered in patients who have tolerated higher doses and after reassessment of the individual benefit-risk, if supplementation with oral haloperidol is required, the combined total dose of haloperidol from both formulations must not exceed the corresponding maximum oral haloperidol dose of 5 mg per day, or the previously administered oral haloperidol dose in patients who have received long- term treatment with oral haloperidol DOSE EQUIVALENCE AND CONVERSION ▶A range of equivalent doses is quoted in the literature; the consensus is that 2 mg per day of oral haloperidol is approximately equivalent to 15 mg per week of haloperidol decanoate depot injection.
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