Indications And Dose
Iron-deficiency anaemia ▶BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: Doses calculated according to body-weight and iron deficit (consult product literature)
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Individual generic drug information
Extracted information for Iron sucrose only.
Iron-deficiency anaemia ▶BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: Doses calculated according to body-weight and iron deficit (consult product literature)
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A complex of ferric hydroxide with sucrose containing 2% (20 mg/mL) of iron. ▶In children Express the dose in terms of elemental iron and iron salt and select the most appropriate preparation; specify both the iron salt and formulation on the prescription. The iron content of artificial formula feeds should also be considered. The most common reason for lack of response in children is poor compliance; poor absorption is rare in children.
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High doses in elderly CAUTIONS, FURTHER INFORMATION ▶Elderly Prescription potentially inappropriate (STOPP Blood and nutrition criteria) at oral doses greater than 200 mg elemental iron daily (no evidence of enhanced iron absorption above these doses). See also Prescribing in the elderly p. 33.
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Extracted information for Iron sucrose only.
→Appendix 1: iron (injectable)
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▶Uncommon Asthenia ▶Rare or very rare Drowsiness. urine discolouration ▶Frequency not known Cold sweat. confusion. level of consciousness decreased. thrombophlebitis ▶Common or very common Constipation. diarrhoea. gastrointestinal discomfort. nausea ▶Uncommon Vomiting ▶Frequency not known Appetite decreased. faeces discoloured SIDE-EFFECTS, FURTHER INFORMATION Iron can be constipating and occasionally lead to faecal impaction. Oral iron, particularly modified-release preparations, can exacerbate diarrhoea in patients with inflammatory bowel disease; care is also needed in patients with intestinal strictures and diverticular disease. Overdose For details on the management of poisoning, see Iron salts, under Emergency treatment of poisoning p. 1430.
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Avoid in first trimester.
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Manufacturer advises caution— monitor iron status to avoid iron overload; avoid where iron overload is a precipitating factor (particularly porphyria cutanea tarda).
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▶Therapeutic response The haemoglobin concentration should rise by about 100–200 mg/100 mL (1–2 g/litre) per day or 2 g/100 mL (20 g/litre) over 3–4 weeks. When the haemoglobin is in the normal range, treatment should be continued for a further 3 months to replenish the iron stores. Epithelial tissue changes such as atrophic glossitis and koilonychia are usually improved, but the response is often slow.
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Extracted information for Iron sucrose only.
Manufacturer advises for intermittent intravenous infusion (Venofer ®), dilute to a concentration of 1 mg/mL with Sodium Chloride 0.9%; give at a rate not exceeding 6.67 mg/minute (consult product literature). Manufacturer advises for slow intravenous injection (Venofer ®), give undiluted at a rate of 1 mL/minute; do not exceed 10 mL (200 mg iron) per injection.
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There can be variation in the licensing of different medicines containing the same drug. Solution for injection A ▶Venofer (Vifor Pharma UK Ltd) Iron (as Iron sucrose) 20 mg per 1 ml Venofer 100mg/5ml solution for injection vials | 5 vial P £43.52 MINERALS AND TRACE ELEMENTS › IRON, ORAL Iron (oral) f
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Extracted information for Iron sucrose only.
Although iron preparations are best absorbed on an empty stomach they can be taken after food to reduce gastro-intestinal side-effects. May discolour stools. eiiii F above
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First line only; read the complete Indications and dose section above.
Doses calculated according to body-weight and
This is a first-line fragment. Read the full Indications and Dose section above.
Candidate age grouping · source page 1103