Therapeutic Action
Antifungal
Source page 181
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Individual generic drug information
Extracted information for ITRACONAZOLE only.
Antifungal
Source page 181
Histoplasmosis and penicilliosis: treatment and secondary prophylaxis Dermatophytosis of the scalp (Tinea capitis)
Source page 181
Extracted information for ITRACONAZOLE only.
Administer with caution and monitor use in patients > 60 years or with hepatic or renal impairment or congestive heart failure. May cause: gastrointestinal disturbances, headache, skin reactions sometimes severe, anaphylactic reaction, hepatic disorders sometimes severe, paraesthesia, oedema, cardiac failure. Stop treatment in the event of anaphylactic reaction, hepatic disorders or severe skin reaction. In case of prolonged treatment, monitor liver function. Do not combine with quinidine (risk of arrhythmia). Avoid or monitor combination with amiodarone, calcium-channel blockers, benzodiazepines, certain antiretrovirals (e.g. indinavir, ritonavir, saquinavir), corticosteroids (dexamethasone, prednisolone), warfarin, carbamazepine, digoxin: increased blood concentration of these drugs. Efficacy of itraconazole may be reduced when combined with: rifampicin, rifabutin, isoniazid, efavirenz, phenytoin, phenobarbital. Do not administer simultaneously with aluminium or magnesium hydroxide: administer 2 hours apart. Pregnancy and breast-feeding: avoid; for histoplasmosis, amphotericin B alone for 4 to 6 weeks is an alternative in pregnant women. Do not administer in the event of dermatophytosis of the scalp (apply a topical treatment until it is possible to use itraconazole).
Source pages 181, 182
Extracted information for ITRACONAZOLE only.
100 mg capsule Also comes in 50 mg/5 ml oral solution.
Source page 181
Histoplasmosis (moderate symptoms) Child: 5 mg/kg once daily for 6 to 12 weeks Adult: 200 mg 3 times daily for 3 days then 200 mg 1 to 2 times daily for 6 to 12 weeks Histoplasmosis (severe symptoms, disseminated form) Same treatment for 12 weeks, preceded by one to 2 weeks of treatment with amphotericin B Penicilliosis (moderate symptoms) Adult: 200 mg 2 times daily for 8 weeks Penicilliosis (severe symptoms) Same treatment for 10 weeks, preceded by 2 weeks of treatment with amphotericin B Secondary prophylaxis of histoplasmosis and penicilliosis Adult: 200 mg once daily as long as required Dermatophytosis of the scalp Child: 3 to 5 mg/kg once daily for 4 weeks Adult: 200 mg once daily for 2 to 4 weeks
Source page 181
Extracted information for ITRACONAZOLE only.
Do not open the capsules; take with meals.
Source page 182
Below 25 °C
Source page 182
Filter the extracted dose blocks for this individual drug.
5 mg/kg once daily for 6 to 12 weeks
Candidate age grouping · source page 181
200 mg 3 times daily for 3 days then 200 mg 1 to 2 times daily for 6 to 12 weeks
Candidate age grouping · source page 181
200 mg 2 times daily for 8 weeks
Candidate age grouping · source page 181
200 mg once daily as long as required
Candidate age grouping · source page 181
3 to 5 mg/kg once daily for 4 weeks
Candidate age grouping · source page 181
200 mg once daily for 2 to 4 weeks
Candidate age grouping · source page 181