Therapeutic Action
Antiseizure (anticonvulsant)
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Individual generic drug information
Extracted information for LEVETIRACETAM only.
Antiseizure (anticonvulsant)
Source page 438
Second-line treatment of convulsive status epilepticus
Source page 438
Extracted information for LEVETIRACETAM only.
Administer with caution to patients with renal impairment (reduce dosage) or heart disorders. May cause: drowsiness, headache, asthenia, dizziness, behavioural disturbances; haematologic disorders, gastrointestinal disturbances, cough, nasopharyngitis; rarely: QT prolongation, hypersensitivity reactions sometimes severe; respiratory depression and coma in the event of overdose. Avoid or monitor the combination with: mefloquine (reduced effect of LEV); drugs that prolong the QT interval (antimalarials, antipsychotics, fluconazole, fluoroquinolones, hydroxyzine, macrolides, ondansetron, etc.); benzodiazepines, opioid analgesics, antipsychotics, first-generation antihistamines (hydroxyzine, promethazine), antidepressants, other antiseizure medications, etc. (increased sedation). Pregnancy and breast-feeding: the risks linked to status epilepticus appear greater than risks linked to LEV.
Source page 439
Extracted information for LEVETIRACETAM only.
500 mg in 5 ml vial (100 mg/ml) for slow IV injection or IV infusion in 0.9% sodium chloride or 5% glucose DO NOT ADMINISTER THE SOLUTION UNDILUTED BY IV INJECTION. DO NOT ADMINISTER BY SC INJECTION.
Source page 438
Loading dose: Child 1 month and over: Use diluted solution: add 3 ml (300 mg) of LEV to 17 ml of 0.9% NaCl to obtain 20 ml of solution containing 15 mg of LEV per ml. Administer 40 mg/kg (max. 3 g) over 10 minutes by IV infusion using a syringe pump or by very slow IV injection. If seizures do not stop after the end of the first dose, readminister half-dose: 20 mg/kg (max. 1.5 g) as above. Do not exceed the total dose of 60 mg/kg or 4.5 g. Adult: 60 mg/kg (max. 4.5 g) single dose over 15 minutes Use diluted solution as above (15 mg/ml) if administered by IV infusion using a syringe pump. Use undiluted solution if administered by IV infusion in a bag of 100 ml of 0.9% NaCl. In children and adult, do not exceed an infusion rate of 5 mg/kg/minute. If maintenance treatment is indicated after the loading dose: change to oral route as soon as possible.
Source pages 438, 439
Extracted information for LEVETIRACETAM only.
Do not mix with other drugs in the same syringe or infusion.
Source page 439
– Below 25 °C
Source page 439
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