Indications And Dose
Hypertension ▶BY MOUTH ▶Adult: Initially 10 mg once daily; usual maintenance 20 mg once daily; maximum 80 mg per day Hypertension, when used in addition to diuretic, in cardiac decompensation or in volume depletion ▶BY MOUTH ▶Adult: Initially 2.5–5 mg once daily; usual maintenance 20 mg once daily; maximum 80 mg per day Short-term treatment following myocardial infarction in haemodynamically stable patients—systolic blood pressure over 120 mmHg ▶BY MOUTH ▶Adult: Initially 5 mg, taken within 24 hours of myocardial infarction, followed by 5 mg, to be taken 24 hours after initial dose, then 10 mg, to be taken 24 hours after second dose, then 10 mg once daily continued → for 6 weeks (or continued if heart failure), temporarily reduce maintenance dose to 5 mg and if necessary 2.5 mg daily if systolic blood pressure 100 mmHg or less during treatment; withdraw if prolonged hypotension occurs during treatment Cardiovascular system (systolic blood pressure less than 90 mmHg for more than 1 hour) Short-term treatment following myocardial infarction in haemodynamically stable patients—systolic blood pressure 100–120 mmHg ▶BY MOUTH ▶Adult: Initially 2.5 mg once daily, maintenance 5 mg once daily, increase to maintenance dose only after at least 3 days of the initial dose, should not be started after myocardial infarction if systolic blood pressure less than 100 mmHg, temporarily reduce maintenance dose to 2.5 mg daily if systolic blood pressure 100 mmHg or less during treatment; withdraw if prolonged hypotension occurs (systolic blood pressure less than 90 mmHg for more than 1 hour) Renal complications of diabetes mellitus ▶BY MOUTH ▶Adult: Initially 2.5–5 mg once daily, adjusted according to response; usual dose 10–20 mg once daily Heart failure (adjunct) (under close medical supervision) ▶BY MOUTH ▶Adult: Initially 2.5 mg once daily; increased in steps of up to 10 mg at least every 2 weeks; maximum 35 mg per day
Source pages 203, 204