Names and pronunciation
(lor-a′ti-deen) Alavert, Childrens Loratadine, Claritin Allergy Childrens, Claritin Childrens, Claritin Reditabs, , Claritin, Clear-Atandine Dimetapp , Triaminic AllerChews
Source page 812
Loading InternPractice…
Individual generic drug information
Extracted information for loratadine only.
(lor-a′ti-deen) Alavert, Childrens Loratadine, Claritin Allergy Childrens, Claritin Childrens, Claritin Reditabs, , Claritin, Clear-Atandine Dimetapp , Triaminic AllerChews
Source page 812
Func. class.: Antihistamine, 2nd generation
Source page 812
Chem. class.: Selective histamine (H1)-receptor antagonist
Source page 812
Do not confuse: loratadine/lovastatin/ LORazepam/losartan
Source page 812
ACTION: Binds to peripheral hista- mine receptors, thereby providing anti- histamine action without sedation
Source page 812
USES: Seasonal rhinitis, chronic idio- pathic urticaria for those ≥2 yr
Source page 812
Extracted information for loratadine only.
CONTRAINDICATIONS: Hyper- sensitivity, acute asthma attacks, lower respiratory tract disease Precautions: Pregnancy, breastfeed- ing, increased intraocular pressure, bronchial asthma, hepatic/renal disease
Source page 812
SIDE EFFECTS CNS: Sedation (more common with increased doses), headache, fatigue, restlessness EENT: Dry mouth
Source page 812
INTERACTIONS Increase: CNS depressant effects—alco- hol, antidepressants, other antihista- mines, sedative/hypnotics, MAOIs Increase: loratadine level—cimetidine, ketoconazole, macrolides (clarithromy- cin, erythromycin) Drug/Herb Increase: CNS depression—chamomile, kava, valerian Drug/Lab Test False negative: skin allergy tests (dis- continue antihistamine 3 days before testing)
Source page 812
Extracted information for loratadine only.
DOSAGE AND ROUTES • Adult and child ≥6 yr: PO 10 mg/day • Child 2-5 yr: PO 5 mg/day Renal/hepatic dose • Adult: PO CCr <30 mL/min or hepatic disease, 10 mg every other day • Child 2-5 yr: PO GFR <50 mL/min; 5 mg every other day
Source page 812
Available forms: Tabs 10 mg; rapid- disintegrating tabs 10 mg; orally disinte- grating tabs 10 mg; syr 1 mg/mL; susp 5 mg/mL, ext rel tab 10 mg
Source page 812
Administer: • Rapid-disintegrating tabs by placing on tongue, to be swallowed after disinte- grated with/without water • Use within 6 mo of opening pouch and immediately after opening blister pack • On empty stomach daily Ext Rel Tab • Do not break, crush, or chew
Source page 812
Extracted information for loratadine only.
Assess: • Allergy: hives, rash, rhinitis; monitor respiratory status • Beers: avoid in older men; may de- crease urinary flow and cause urinary retention • Pregnancy/breastfeeding: use only if clearly needed; cautious use in breast- feeding
Source page 813
Evaluate: • Therapeutic response: absence of run- ning or congested nose, other allergy symptoms
Source page 813
CLINICAL CONSIDERATIONS
Source page 813
Patient and caregiver information: • To avoid driving, other hazardous ac- tivities if drowsiness occurs • To avoid use of other CNS depres- sants HIGH ALERT
Source page 813
Extracted information for loratadine only.
PHARMACOKINETICS Onset 1-3 hr, peak 8-12 hr, duration 24 hr, metabolized in liver to active metabolites, excreted in urine, active metabolite desloratadine half-life 20 hr
Source page 812
Filter the extracted dose blocks for this individual drug.
• Adult and child ≥6 yr: PO 10 mg/day
Candidate age grouping · source page 812
• Child 2-5 yr: PO 5 mg/day Renal/hepatic dose
Candidate age grouping · source page 812
• Adult: PO CCr <30 mL/min or hepatic disease, 10 mg every other day
Candidate age grouping · source page 812
• Child 2-5 yr: PO GFR <50 mL/min; 5 mg every other day
Candidate age grouping · source page 812