Therapeutic Action
Uterine relaxant
Source page 233
Loading InternPractice…
Individual generic drug information
Extracted information for NIFEDIPINE only.
Uterine relaxant
Source page 233
Threatened premature labour
Source page 233
Extracted information for NIFEDIPINE only.
Do not administer to patients with severe cardiac disease (recent myocardial infarction, unstable angina). Do not administer if systolic blood pressure is below 90 mmHg. May cause: headache, flushing, peripheral oedema (common adverse effects at the start of treatment); dizziness, hypotension, tachycardia, nausea, gingival hyperplasia, rash. Stop nifedipine if ischaemic chest pain occurs or existing pain increases after starting treatment. Do not combine with magnesium sulphate, salbutamol IV, and other calcium channel blockers. Monitor combination with cimetidine (enhances hypotensive effects), phenytoin (risk of phenytoin overdose), rifampicin (efficacy of nifedipine diminished), itraconazole (increased risk of oedema), beta-blockers (increased adverse cardiac effects). Pregnancy: CONTRA-INDICATED during the first trimester. Never administer sublingually (risk of foetal death from placental hypoperfusion). Breast-feeding: avoid
Source pages 233, 234
Extracted information for NIFEDIPINE only.
10 mg immediate-release soft capsule or tablet
Source page 233
10 mg by oral route, to be repeated every 15 minutes if uterine contractions persist (max. 4 doses or 40 mg), then 20 mg by oral route every 6 hours The total duration of treatment is 48 hours.
Source page 233
Extracted information for NIFEDIPINE only.
Nifedipine is a calcium channel blocker that is also used in the management of hypertension at doses of 10 to 40 mg 2 times daily or 20 to 90 mg once daily, depending on the sustained- release form used.
Source page 234
– Below 25 °C
Source page 234
Filter the extracted dose blocks for this individual drug.