Drug Action
Palonosetron is a specific 5HT3-receptor antagonist which blocks 5HT3 receptors in the gastro- intestinal tract and in the CNS.
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Individual generic drug information
Extracted information for Palonosetron only.
Palonosetron is a specific 5HT3-receptor antagonist which blocks 5HT3 receptors in the gastro- intestinal tract and in the CNS.
Source page 478
Moderately emetogenic chemotherapy ▶INITIALLY BY MOUTH ▶Adult: 500 micrograms, dose to be taken 1 hour before treatment, alternatively (by intravenous injection) 250 micrograms for 1 dose, dose to be administered over 30 seconds, 30 minutes before treatment Severely emetogenic chemotherapy ▶BY INTRAVENOUS INJECTION ▶Adult: 250 micrograms for 1 dose, dose to be administered over 30 seconds, 30 minutes before treatment
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History of constipation. intestinal obstruction. susceptibility to QT-interval prolongation (including electrolyte disturbances)
Source page 478
Extracted information for Palonosetron only.
→Appendix 1: palonosetron
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GENERAL SIDE-EFFECTS ▶Common or very common Constipation. headache SPECIFIC SIDE-EFFECTS ▶Common or very common ▶With intravenous use Diarrhoea. dizziness. electrolyte imbalance. metabolic disorder ▶Uncommon ▶With intravenous use Amblyopia. anxiety. appetite decreased. arrhythmias. arthralgia. asthenia. drowsiness. dry mouth. dyspepsia. euphoric mood. eye irritation. feeling hot. fever. flatulence. glycosuria. hiccups. hyperbilirubinaemia. hyperglycaemia. hypertension. hypotension. influenza like illness. motion sickness. myocardial ischaemia. paraesthesia. peripheral neuropathy. QT interval prolongation. skin reactions. sleep disorders. tinnitus. urinary retention. vasodilation. vein discolouration ▶With oral use Atrioventricular block. dyspnoea. eye swelling. insomnia. myalgia ▶Rare or very rare ▶With intravenous use Shock
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Avoid—no information available.
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Avoid—no information available.
Source page 479
Extracted information for Palonosetron only.
There can be variation in the licensing of different medicines containing the same drug. Solution for injection ▶Palonosetron (Non-proprietary) Palonosetron (as Palonosetron hydrochloride) 50 microgram per 1 ml Palonosetron 250micrograms/5ml solution for injection vials | 1 vial P £53.10 (Hospital only) | 10 vial P £646.90 ▶Aloxi (Chugai Pharma UK Ltd) Palonosetron (as Palonosetron hydrochloride) 50 microgram per 1 ml Aloxi 250micrograms/5ml solution for injection vials | 1 vial P £55.89 Capsule ▶Aloxi (Chugai Pharma UK Ltd) Palonosetron (as Palonosetron hydrochloride) 500 microgram Aloxi 500microgram capsules | 1 capsule P £55.89
Source page 479
Extracted information for Palonosetron only.
Driving and skilled tasks Dizziness or drowsiness may affect performance of skilled tasks (e.g. driving).
Source page 479
Filter the extracted dose blocks for this individual drug.
First line only; read the complete Indications and dose section above.
500 micrograms, dose to be taken 1 hour before
This is a first-line fragment. Read the full Indications and Dose section above.
Candidate age grouping · source page 478
First line only; read the complete Indications and dose section above.
250 micrograms for 1 dose, dose to be
This is a first-line fragment. Read the full Indications and Dose section above.
Candidate age grouping · source page 478