Therapeutic Action
Antiseizure (anticonvulsant), sedative
Source page 475
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Individual generic drug information
Extracted information for PHENOBARBITAL only.
Antiseizure (anticonvulsant), sedative
Source page 475
Second-line treatment of convulsive status epilepticus
Source page 475
Extracted information for PHENOBARBITAL only.
Do not administer to patients with severe impairment of respiratory, renal or hepatic function (risk of accumulation). Administer with caution in children, older patients and patients with mild to moderate impairment of respiratory, renal or hepatic function. May cause : drowsiness, dizziness, headache, behavioural disturbances; dose-dependant respiratory depression; hypotension, apnoea, laryngospasm, shock, especially if administered rapidly by IV route and if large doses are administered; haematologic disorders, gastrointestinal disturbances; hypersensitivity reactions sometimes severe; coma in the event of overdose. Monitor closely respiratory rate and blood pressure during and after administration. Avoid or monitor the combination with: mefloquine (reduced effect of PB); benzodiazepines, opioid analgesics, antipsychotics, first-generation antihistamines (hydroxyzine, promethazine), antidepressants, other antiseizure medications, etc. (increased sedation). Use with extreme caution with benzodiazepines and opioids analgesics (increased risk of respiratory depression). PB may reduce the effect of many drugs: diazepam, midazolam, antimicrobials, some antiretrovirals, corticosteroids, tricyclic antidepressants, itraconazole, direct-acting antivirals for chronic hepatitis C, warfarin, etc. Adjust dosage if necessary. implants and oral contraceptives: use condoms until next menstruation. Pregnancy and breast-feeding: prefer a safer drug (levetiracetam). If PB is the only option, the risks linked to status epilepticus appear greater than risks linked to PB.
Source page 476
Extracted information for PHENOBARBITAL only.
200 mg in 1 ml ampoule (200 mg/ml) for IV infusion in 0.9% sodium chloride DO NOT ADMINISTER BY DIRECT IV INJECTION. DO NOT ADMINISTER THE SOLUTION UNDILUTED. DO NOT ADMINISTER BY SC INJECTION (risk of necrosis).
Source page 475
Loading dose: Child 1 month and over: Use diluted solution: add 1 ml (200 mg) of PB to 9 ml of 0.9% NaCl to obtain 10 ml of solution containing 20 mg of PB per ml. Administer 20 mg/kg (max. 1 g) over 20 minutes by IV infusion using a syringe pump (or only if not available, using a pediatric infusion set). If seizures do not stop after the end of the first dose, readminister half dose: 10 mg/kg as above. Adult: 15 mg/kg (max. 1 g) single dose over 15 minutes Use diluted solution as above (20 mg/ml) if administered by IV infusion using a syringe pump. Use undiluted solution if administered by IV infusion in a bag of 100 ml of 0.9% NaCl. Do not exceed an infusion rate of 1 mg/kg/minute in children and 100 mg/minute in adults. If maintenance treatment is indicated after the loading dose: change to oral route as soon as possible.
Source pages 475, 476
Extracted information for PHENOBARBITAL only.
PB is subject to international controls: follow national regulations. Do not mix with other drugs in the same syringe or infusion.
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– Below 25 °C
Source page 476
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