Indications And Dose
Induction of anaesthesia using 0.5% or 1% injection ▶BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult 18–54 years: Usual dose 1.5–2.5 mg/kg, to be administered at a rate of 20–40 mg every 10 seconds until response, for debilitated patients use dose for 55 years and over ▶Adult 55 years and over: Usual dose 1–1.5 mg/kg, to be administered at a rate of 20 mg every 10 seconds until response Induction of anaesthesia using 2% injection ▶BY INTRAVENOUS INFUSION ▶Adult 18–54 years: Usual dose 1.5–2.5 mg/kg, to be administered at a rate of 20–40 mg every 10 seconds until response. For debilitated patients use dose for 55 years and over ▶Adult 55 years and over: Usual dose 1–1.5 mg/kg, to be administered at a rate of 20 mg every 10 seconds until response Maintenance of anaesthesia using 1% injection ▶INITIALLY BY INTRAVENOUS INFUSION ▶Adult: Usual dose 4–12 mg/kg/hour, alternatively (by slow intravenous injection) 25–50 mg, dose may be repeated according to response, for debilitated patients use dose for elderly ▶Elderly: Usual dose 3–6 mg/kg/hour, alternatively (by slow intravenous injection) 25–50 mg, dose may be repeated according to response Maintenance of anaesthesia using 2% injection ▶BY INTRAVENOUS INFUSION ▶Adult: Usual dose 4–12 mg/kg/hour, for debilitated patients use dose for elderly ▶Elderly: Usual dose 3–6 mg/kg/hour Sedation of ventilated patients in intensive care using 1% or 2% injection ▶BY CONTINUOUS INTRAVENOUS INFUSION ▶Adult: Usual dose 0.3–4 mg/kg/hour, adjusted according to response Induction of sedation for surgical and diagnostic procedures using 0.5% or 1% injection ▶BY SLOW INTRAVENOUS INJECTION ▶Adult: Initially 0.5–1 mg/kg, to be administered over 1–5 minutes, dose and rate of administration adjusted according to desired level of sedation and response Maintenance of sedation for surgical and diagnostic procedures using 0.5% injection ▶INITIALLY BY INTRAVENOUS INFUSION ▶Adult: Initially 1.5–4.5 mg/kg/hour, dose and rate of administration adjusted according to desired level of sedation and response, followed by (by slow intravenous injection) 10–20 mg, (if rapid increase in sedation required), patients over 55 years or debilitated may require lower initial dose and rate of administration Maintenance of sedation for surgical and diagnostic procedures using 1% injection ▶INITIALLY BY INTRAVENOUS INFUSION ▶Adult: Initially 1.5–4.5 mg/kg/hour, dose and rate of administration adjusted according to desired level of sedation and response, followed by (by slow intravenous injection) 10–20 mg, (if rapid increase in sedation required), patients over 55 years or debilitated may require lower initial dose and rate of administration Maintenance of sedation for surgical and diagnostic procedures using 2% injection ▶INITIALLY BY INTRAVENOUS INFUSION ▶Adult: Initially 1.5–4.5 mg/kg/hour, dose and rate of administration adjusted according to desired level of sedation and response, followed by (by slow intravenous injection) 10–20 mg, using 0.5% or 1% injection (if rapid increase in sedation required), patients over 55 years or debilitated may require lower initial dose and rate of administration
Source pages 1422, 1423