Names and pronunciation
(soo-kral′fate) Carafate
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Individual generic drug information
Extracted information for sucralfate only.
(soo-kral′fate) Carafate
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Func. class.: Protectant, antiulcer
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Chem. class.: Aluminum hydroxide, sulfated sucrose
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ACTION: Forms a complex that adheres to ulcer site, adsorbs pepsin
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USES: Duodenal ulcer, oral mucositis, stomatitis after radiation of head and neck Unlabeled uses: Gastric/aphthous ulcers, gastroesophageal reflux, NSAID- induced ulcer prophylaxis, proctitis, sto- matitis, stress gastritis prophylaxis, C. difficile
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Extracted information for sucralfate only.
CONTRAINDICATIONS: Hyper sensitivity Precautions: Pregnancy, breastfeeding, children, renal failure; hypoglycemia (diabetics)
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INTERACTIONS Decrease: action of tetracyclines, phe- nytoin, fat-soluble vitamins, digoxin, ketoconazole, theophylline Decrease: absorption of fluoroquino lones Decrease: absorption of sucralfate— antacids, cimetidine, raNITIdine NURSING CONSIDERATIONS
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Extracted information for sucralfate only.
DOSAGE AND ROUTES Duodenal ulcers • Adult: PO 1 g qid 1 hr before meals, at bedtime • Child: PO 40-80 mg/kg/day divided Aphthous ulcer/stomatitis (unlabeled) • Adult: PO 5-10 mL (500 mg-1 g) swished in mouth for several min; spit or swallow qid Gastric ulcer/NSAID-induced ulcer prophylaxis/esophagitis/GERD (unlabeled) • Adult: PO 1 g qid, 1 hr before meals and at bedtime
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Available forms: Tabs 1 g; oral susp 1 g/10 mL
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Administer: PO route • Do not crush or chew tabs; tabs may be broken or dissolved in water • Do not take antacids 30 min before or after sucralfate • On an empty stomach 1 hr before meals or other medications and at bed- time • Store at room temperature Side effects GI: Dry mouth, constipation
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Extracted information for sucralfate only.
Assess: • GI symptoms: abdominal pain, blood in stools • Hypoglycemia: may occur in patients with diabetes mellitus; monitor blood glucose carefully
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Evaluate: • Therapeutic response: absence of pain, GI complaints
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Patient and caregiver information: S • To take on empty stomach • To take full course of therapy; not to use for >8 wk; to avoid smoking • To avoid antacids, milk, alkaline water within 1 hr of this product • To increase fluids, bulk, exercise to lessen constipation
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Extracted information for sucralfate only.
PHARMACOKINETICS PO: Duration up to 6 hr
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Filter the extracted dose blocks for this individual drug.
Duodenal ulcers
• Adult: PO 1 g qid 1 hr before meals, at bedtime
Candidate age grouping · source page 1237
Duodenal ulcers
• Child: PO 40-80 mg/kg/day divided Aphthous ulcer/stomatitis (unlabeled)
Candidate age grouping · source page 1237
Duodenal ulcers
• Adult: PO 5-10 mL (500 mg-1 g) swished in mouth for several min; spit or swallow qid Gastric ulcer/NSAID-induced ulcer prophylaxis/esophagitis/GERD (unlabeled)
Candidate age grouping · source page 1237
Duodenal ulcers
• Adult: PO 1 g qid, 1 hr before meals and at bedtime
Candidate age grouping · source page 1237