Therapeutic Action
Antiprotozoal
Source page 271
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Individual generic drug information
Extracted information for PYRIMETHAMINE only.
Antiprotozoal
Source page 271
Treatment and secondary prophylaxis of toxoplasmosis in immunodeficient patients, in combination with sulfadiazine or clindamycin Primary prophylaxis of toxoplasmosis in immunodeficient patients, in combination with dapsone (only if co-trimoxazole cannot be used) Second-line treatment of isosporiasis in immunodeficient patients (only if co-trimoxazole cannot be used)
Source page 271
Extracted information for PYRIMETHAMINE only.
Do not administer to patients with severe renal or hepatic impairment. May cause: gastrointestinal disturbances, seizures, leucopenia, thrombocytopenia, megaloblastic anaemia due to folic acid deficiency. Administer calcium folinate to prevent folic acid deficiency. Avoid if possible combination with other folate antagonists: co-trimoxazole, methotrexate (increased risk of folic acid deficiency). Monitor combination with zidovudine (increased risk of zidovudine-associated haematotoxicity). Pregnancy: CONTRA-INDICATED during the first trimester Breast-feeding: no contra-indication; however avoid concomitant administration of other folate antagonists.
Source pages 271, 272
Extracted information for PYRIMETHAMINE only.
25 mg tablet
Source page 271
Treatment of toxoplasmosis Adult: 2 doses of 100 mg on D1, then 75 to 100 mg once daily for at least 6 weeks Secondary prophylaxis of toxoplasmosis Adult: 25 to 50 mg once daily, as long as necessary Primary prophylaxis of toxoplasmosis Adult: 50 to 75 mg once weekly, as long as necessary Treatment of isosporiasis Adult: 50 to 75 mg once daily for 10 days
Source page 271
Extracted information for PYRIMETHAMINE only.
The combination of sulfadoxine/pyrimethamine is used for the treatment of uncomplicated falciparum malaria.
Source page 272
Below 25 °C
Source page 272
Filter the extracted dose blocks for this individual drug.
2 doses of 100 mg on D1, then 75 to 100 mg once daily for at least 6 weeks
Candidate age grouping · source page 271
25 to 50 mg once daily, as long as necessary
Candidate age grouping · source page 271
50 to 75 mg once weekly, as long as necessary
Candidate age grouping · source page 271
50 to 75 mg once daily for 10 days
Candidate age grouping · source page 271