Individual generic drug information

testosterone

Reference monograph

Part of registered formulation

TESTOSTERONE

Reference record: Testosterone
Source: BNF 80 (2020–2021)
Printed source pages: 833, 834
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Testosterone only.

Indications And Dose

Low sexual desire in postmenopausal women (administered on expert advice) ▶BY TRANSDERMAL APPLICATION ▶Adult: Apply 50 mg every week, the contents of a 5-g sachet or 5-g tube (containing 50 mg/5 g of testosterone) to be divided for daily dosing and applied to non-hair areas, such as the abdomen or upper thighs, over the period of 1 week TESTAVAN ® Hypogonadism due to androgen deficiency in men ▶BY TRANSDERMAL APPLICATION ▶Adult: Apply 23 mg once daily; increased in steps of 23 mg, adjusted according to response; maximum 69 mg per day DOSE EQUIVALENCE AND CONVERSION ▶For Testavan ® One pump actuation delivers 1.15 g of gel containing 23 mg of testosterone. TESTIM ® Hypogonadism due to testosterone deficiency in men ▶BY TRANSDERMAL APPLICATION ▶Adult: Apply 50 mg once daily, subsequent application adjusted according to response; maximum 100 mg per day DOSE EQUIVALENCE AND CONVERSION ▶For Testim ® One tube of 5 g contains 50 mg testosterone. TESTOGEL ® 16.2MG/G Hypogonadism due to androgen deficiency in men ▶BY TRANSDERMAL APPLICATION ▶Adult: Apply 40.5 mg once daily; increased in steps of 20.25 mg, adjusted according to response; maximum 81 mg per day DOSE EQUIVALENCE AND CONVERSION ▶For Testogel ® 16.2 mg/g One pump actuation delivers 1.25 g of gel containing 20.25 mg of testosterone. TESTOGEL ® 50MG/5G Hypogonadism due to androgen deficiency in men ▶BY TRANSDERMAL APPLICATION ▶Adult: Apply 50 mg once daily; increased in steps of 25 mg, adjusted according to response; maximum 100 mg per day DOSE EQUIVALENCE AND CONVERSION ▶For Testogel ® 50 mg/5g One sachet of 5 g contains 50 mg of testosterone. TOSTRAN ® Hypogonadism due to testosterone deficiency in men ▶BY TRANSDERMAL APPLICATION ▶Adult: Apply 60 mg once daily, subsequent application adjusted according to response; maximum 80 mg per day DOSE EQUIVALENCE AND CONVERSION ▶For Tostran ® 1 g of gel contains 20 mg testosterone. l UNLICENSED USE g Testosterone is used for the treatment of low sexual desire in postmenopausal women, l but is not licensed for this indication.

Source page 833

National Funding Access Decisions

Scottish Medicines Consortium (SMC) decisions SMC No. SMC2152 The Scottish Medicines Consortium has advised (April 2019) that testosterone gel (Testavan ®) is accepted for restricted use within NHS Scotland for the treatment of adult male hypogonadism, when testosterone deﬁciency has been conﬁrmed by clinical features and biochemical tests, and in patients who require a transdermal delivery system.

Source page 833

Safety

Extracted information for Testosterone only.

Side Effects

▶Common or very common Hypertriglyceridaemia ▶Frequency not known Anaemia. deep vein thrombosis. electrolyte imbalance. frontal balding (in women). hair growth unwanted (in women). hypertrichosis. malaise. muscle cramps. musculoskeletal pain. testicular disorder. vasodilation. voice lowered (in women) SIDE-EFFECTS, FURTHER INFORMATION When used for low sexual desire in post-menopausal women The long- term effects of testosterone in this patient group are largely unknown, but side-effects can include growth of unwanted hair, frontal balding and deepening of the voice.

Source page 833

Dose and formulations

Extracted information for Testosterone only.

Directions For Administration

Avoid skin contact with gel application sites to prevent testosterone transfer to other people, especially pregnant women and children— consult product literature. TOSTRAN ® Apply gel on clean, dry, intact skin of abdomen Endocrine system or both inner thighs, preferably in the morning. Gently rub in with a ﬁnger until dry before dressing. Wash hands with soap and water after applying gel; avoid washing application site for at least 2 hours. Not to be applied on genital area. TESTOGEL ® 50MG/5G Apply thin layer of gel on clean, dry, healthy skin such as shoulders, arms or abdomen, immediately after sachet is opened. Not to be applied on genital area as high alcohol content may cause local irritation. Allow to dry for 3–5 minutes before dressing. Wash hands with soap and water after applying gel, avoid shower or bath for at least 6 hours. TESTIM ® Squeeze entire content of tube on to one palm and apply as a thin layer on clean, dry, healthy skin of shoulder or upper arm, preferably in the morning after washing or bathing (if 2 tubes required use 1 per shoulder or upper arm); rub in and allow to dry before putting on clothing to cover site; wash hands with soap after application; avoid washing application site for at least 6 hours. TESTOGEL ® 16.2MG/G Apply thin layer of gel on clean, dry, healthy skin over right and left upper arms and shoulders. Not to be applied on genital area as high alcohol content may cause local irritation. Allow to dry for 3–5 minutes before dressing. Wash hands with soap and water after applying gel, and cover the site with clothing once gel dried; avoid shower or bath for at least 2 hours. TESTAVAN ® Manufacturer advises apply one pump actuation of gel evenly onto clean, dry, intact skin over upper arm and shoulder using the applicator, without getting any gel on the hands—repeat on opposite upper arm and shoulder if two pump actuations are required, and repeat again on initial upper arm and shoulder if three pump actuations are required. Allow to dry completely before dressing and cover application site with clothing. Wash hands with soap and water immediately if gel was touched during application; avoid shower or bath for at least 2 hours.

Source page 833

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Gel CAUTIONARY AND ADVISORY LABELS 15 EXCIPIENTS: May contain Butylated hydroxytoluene, propylene glycol ▶Testavan (Ferring Pharmaceuticals Ltd) Testosterone 20 mg per 1 gram Testavan 20mg/g transdermal gel | 85.5 gram P £25.22 DT = £25.22 e ▶Testim (Endo Ventures Ltd) Testosterone 50 mg Testim 50mg/5g gel | 30 tube P £30.50 DT = £30.50 e ▶Testogel (Besins Healthcare (UK) Ltd) Testosterone 50 mg Testogel 50mg/5g gel sachets | 30 sachet P £31.11 DT = £31.11 e Testosterone 16.2 mg per 1 gram Testogel 16.2mg/g gel | 88 gram P £31.11 DT = £31.11 e ▶Tostran (Kyowa Kirin Ltd) Testosterone 20 mg per 1 gram Tostran 2% gel | 60 gram P £28.63 DT = £28.63 e

Source pages 833, 834

Clinical care

Extracted information for Testosterone only.

Patient And Carer Advice

Patient or carer should be given advice on how to administer testosterone gel.

Source page 833

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

Apply 50 mg every week, the contents of a 5-g

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 833

Adults

First line only; read the complete Indications and dose section above.

Apply 23 mg once daily; increased in steps of

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 833

Adults

First line only; read the complete Indications and dose section above.

Apply 50 mg once daily, subsequent application

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 833

Adults

First line only; read the complete Indications and dose section above.

Apply 40.5 mg once daily; increased in steps of

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 833

Adults

First line only; read the complete Indications and dose section above.

Apply 50 mg once daily; increased in steps of

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 833

Adults

First line only; read the complete Indications and dose section above.

Apply 60 mg once daily, subsequent application

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 833

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

testosterone

Reference monograph

Part of registered formulation

TESTOSTERONE

Reference record: Testosterone
Source: BNF 80 (2020–2021)
Printed source pages: 833, 834
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Testosterone only.

Indications And Dose

Source page 833

National Funding Access Decisions

Source page 833

Safety

Extracted information for Testosterone only.

Side Effects

Source page 833

Dose and formulations

Extracted information for Testosterone only.

Directions For Administration

Source page 833

Medicinal Forms

Source pages 833, 834

Clinical care

Extracted information for Testosterone only.

Patient And Carer Advice

Patient or carer should be given advice on how to administer testosterone gel.

Source page 833

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

Apply 50 mg every week, the contents of a 5-g

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 833

Adults

First line only; read the complete Indications and dose section above.

Apply 23 mg once daily; increased in steps of

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 833

Adults

First line only; read the complete Indications and dose section above.

Apply 50 mg once daily, subsequent application

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 833

Adults

First line only; read the complete Indications and dose section above.

Apply 40.5 mg once daily; increased in steps of

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 833

Adults

First line only; read the complete Indications and dose section above.

Apply 50 mg once daily; increased in steps of

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 833

Adults

First line only; read the complete Indications and dose section above.

Apply 60 mg once daily, subsequent application

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 833

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.